Keep away from or Use Alternate Drug. Product labeling for PO topotecan suggests keeping away from concomitant utilization of P-gp inhibitors; the conversation with IV topotecan can be significantly less intense but continues to be probable of clinical significance
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willow bark raises outcomes of aspirin by pharmacodynamic synergism. Small/Importance Unfamiliar. Willow bark consists of salicylic acid, which can have additive outcomes/toxicity with salicylate medicines.
aspirin improves amounts of pemetrexed by unspecified conversation system. Keep away from or Use Alternate Drug. Interrupt dosing in all individuals taking NSAIDs with prolonged elimination 50 %-life for a minimum of 5d just before, the working day of, and second pursuing pemetrexed administration.
aspirin, bivalirudin. Either improves toxicity of the other by anticoagulation. Use Caution/Observe. The need for simultaneous utilization of reduced-dose aspirin and anticoagulant or antiplatelet agents are frequent for people with cardiovascular disease; monitor intently.
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aspirin, anagrelide. Either increases toxicity of another by pharmacodynamic synergism. Use Warning/Keep track of. The need for simultaneous usage of minimal-dose aspirin and anticoagulant or antiplatelet brokers are popular for sufferers with cardiovascular disease; will increase possibility of bleeding; monitor closely.
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aspirin decreases results of candesartan by pharmacodynamic antagonism. Modify Therapy/Observe Carefully. NSAIDs lower synthesis of vasodilating renal prostaglandins, and thus impact fluid homeostasis and could diminish antihypertensive impact.
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aspirin, antithrombin alfa. Either increases toxicity of one other by anticoagulation. Use Warning/Monitor. The need for simultaneous use of very low-dose aspirin and anticoagulant or antiplatelet brokers are widespread for individuals with cardiovascular disease; observe intently.
aspirin, bivalirudin. Both improves toxicity of another by anticoagulation. Use Caution/Check. The need for simultaneous usage of minimal-dose aspirin and anticoagulant or antiplatelet brokers are typical for sufferers with cardiovascular disease; monitor closely.